ディレクターの経歴と資格

私の名前はパトリック・リーヒーです。私は生物科学の博士号を持ち、英語を母国語として話します。また、アメリカ合衆国でバイオメディカル及び生命科学の分野において、１１年の研究経験を持っています。私はすでに多くの科学論文を一流誌に発表しており、また、Journal of Biological Chemistryに投稿された論文の審査員の経験もあります。

　

　

　

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Here are some articles published by our director on diabetes related issues.


　　Leahy, P., Crawford, D.R., Chaudhury, A., Gronostajski, R., Grosmann, G. and Hanson, R.W. CREB-binding protein (CBP)co-ordinates the function of multiple transcription factors including Nuclear Factor I to regulate Phosphoenolpyruvate Carboxykinase (GTP) gene transcription. Journal of Biological Chemistry 274, 8813-8822
　　Leahy, P., Hanson, R.W., and Croniger, C. 1998 Molecular and Cellular Adaptations to Carbohydrate and Fat Intake. European Journal of Clinical Nutrition (accepted, in press)
　　Crawford, D.R., Leahy, P., Hu, C.Y., Chaudhury, A., Gronostajski, R., Grosmann, G. Woods, J and Hanson, R.W.. Nuclear Factor I Regulates Expression of the Gene for Phosphoenolpyruvate Carboxykinase (GTP).Journal of Biological Chemistry. (1998) 273, 13387 - 13390
　　Leahy, P. , Carmichael, G.C. and Rossomondo, E.F.. Biotinylation of plasmid expression vectors causes loss of biological activity. Nucleic acids Research (1997) 25, 449-50
　　Leahy, P. , Carmichael, G.C. and Rossomondo, E.F.. Novel Biotinylated Plasmid Expression Vectors Retain Biological Function and Can Bind Streptavidin. Bioconjugate Chemistry. (1996) 7, 545-551
　　Saker, F., Ybarra, J., Leahy, P. Hanson, R.W., Kalhan, S.C. and Ismail-Beigi, F. Mechanism of Glycemia-Lowering Effect of Cobalt Chloride in the Diabetic Rat. American Journal of Physiology: Endocrinology and Metabolism (1998) 274, E984-E991
　　Croniger, C., Leahy, P. Reshef, L. and Hanson, R.W. C/EBP and the control of Phosphoenolpyruvate Carboxykinase Gene Transcription in the Liver. Journal of Biological Chemistry, (1998, submitted)
　　Blennemann, B., Leahy, P., Kim, T.S. and Freake, H.C.. Tissue specific regulation of lipogenic mRNAs by thyroid hormone. Molecular and Cellular Endocrinology, (1995) 110: 1-8.
　　Leahy, P. , Carmichael, G.C. and Rossomondo, E.F.. Simple protocol modifications yield a ten fold more sensitive CAT assay. Biotechniques (1995) 19, 894-8
　　Yeh, W.-J., Leahy, P. and Freake, H.C.,. Regulation of brown adipose Tissue lipogenesis by thyroid hormone and the sympathetic nervous system. American journal of physiology, (1993) 265: E252-E258.
　　Leahy, P., Carmichael, G.C. and Rossomondo, E.F.. Novel plasmid constructs for general and receptor mediated transfections. FASEB Journal, (1995) 9: A1400.
　　Kim, T.S., Leahy, P. and Freake, H.C.. Promoter usage determines tissue specific responsiveness of the rat acetyl-CoA carboxylase gene. Biochem. Biophys. Res. Commun. (1996) 225, 647-53
　　Kim, T.S., Leahy P. and Freake, H.C.. Promoter usage determines tissue specific responsiveness of rat Acetyl- CoA Carboxylase. Faseb journal (1995) A 468, 2716.
　　Leahy, P. and Laufer, H., 1993. Defining a molecular role for methyl farnesoate in the regulation of crustacean reproduction. Proceedings of the National Seagrant Workshop on Crustacean Endocrinology/Reproductive Biology. NOAA, Silver Spring, MD, 1993
　　Laufer, H and Leahy, P., 1993. Endocrinology of Crustacean Resources. Proceedings of the National Seagrant Workshop on Crustacean Endocrinology/Reproductive Biology. NOAA, Silver Spring, MD, 1993.