Director's background and qualifications.

My name is Patrick Leahy. I am a native English speaker with a Ph.D. in the biological sciences plus 11 years of research experience in Biomedical and Life-Sciences in the U.S.A. I have published a number of scientific articles in top-quality scientific journals and I have acted as reviewer for papers submitted to the Journal of Biological Chemistry .

 

 

 

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Here are some articles published by our director on diabetes related issues.


    Leahy, P., Crawford, D.R., Chaudhury, A., Gronostajski, R., Grosmann, G. and Hanson, R.W. CREB-binding protein (CBP)co-ordinates the function of multiple transcription factors including Nuclear Factor I to regulate Phosphoenolpyruvate Carboxykinase (GTP) gene transcription. Journal of Biological Chemistry 274, 8813-8822
    Leahy, P., Hanson, R.W., and Croniger, C. 1998 Molecular and Cellular Adaptations to Carbohydrate and Fat Intake. European Journal of Clinical Nutrition (accepted, in press)
    Crawford, D.R., Leahy, P., Hu, C.Y., Chaudhury, A., Gronostajski, R., Grosmann, G. Woods, J and Hanson, R.W.. Nuclear Factor I Regulates Expression of the Gene for Phosphoenolpyruvate Carboxykinase (GTP).Journal of Biological Chemistry. (1998) 273, 13387 - 13390
    Leahy, P. , Carmichael, G.C. and Rossomondo, E.F.. Biotinylation of plasmid expression vectors causes loss of biological activity. Nucleic acids Research (1997) 25, 449-50
    Leahy, P. , Carmichael, G.C. and Rossomondo, E.F.. Novel Biotinylated Plasmid Expression Vectors Retain Biological Function and Can Bind Streptavidin. Bioconjugate Chemistry. (1996) 7, 545-551
    Saker, F., Ybarra, J., Leahy, P. Hanson, R.W., Kalhan, S.C. and Ismail-Beigi, F. Mechanism of Glycemia-Lowering Effect of Cobalt Chloride in the Diabetic Rat. American Journal of Physiology: Endocrinology and Metabolism (1998) 274, E984-E991
    Croniger, C., Leahy, P. Reshef, L. and Hanson, R.W. C/EBP and the control of Phosphoenolpyruvate Carboxykinase Gene Transcription in the Liver. Journal of Biological Chemistry, (1998, submitted)
    Blennemann, B., Leahy, P., Kim, T.S. and Freake, H.C.. Tissue specific regulation of lipogenic mRNAs by thyroid hormone. Molecular and Cellular Endocrinology, (1995) 110: 1-8.
    Leahy, P. , Carmichael, G.C. and Rossomondo, E.F.. Simple protocol modifications yield a ten fold more sensitive CAT assay. Biotechniques (1995) 19, 894-8
    Yeh, W.-J., Leahy, P. and Freake, H.C.,. Regulation of brown adipose Tissue lipogenesis by thyroid hormone and the sympathetic nervous system. American journal of physiology, (1993) 265: E252-E258.
    Leahy, P., Carmichael, G.C. and Rossomondo, E.F.. Novel plasmid constructs for general and receptor mediated transfections. FASEB Journal, (1995) 9: A1400.
    Kim, T.S., Leahy, P. and Freake, H.C.. Promoter usage determines tissue specific responsiveness of the rat acetyl-CoA carboxylase gene. Biochem. Biophys. Res. Commun. (1996) 225, 647-53
    Kim, T.S., Leahy P. and Freake, H.C.. Promoter usage determines tissue specific responsiveness of rat Acetyl- CoA Carboxylase. Faseb journal (1995) A 468, 2716.
    Leahy, P. and Laufer, H., 1993. Defining a molecular role for methyl farnesoate in the regulation of crustacean reproduction. Proceedings of the National Seagrant Workshop on Crustacean Endocrinology/Reproductive Biology. NOAA, Silver Spring, MD, 1993
    Laufer, H and Leahy, P., 1993. Endocrinology of Crustacean Resources. Proceedings of the National Seagrant Workshop on Crustacean Endocrinology/Reproductive Biology. NOAA, Silver Spring, MD, 1993.